Interdependency of cell adhesion, force generation and extracellular proteolysis in matrix remodeling
نویسندگان
چکیده
منابع مشابه
Interdependency of cell adhesion, force generation and extracellular proteolysis in matrix remodeling.
It is becoming increasingly evident that the micromechanics of cells and their environment determine cell fate and function as much as soluble molecular factors do. We hypothesized that extracellular matrix proteolysis by membrane type 1 matrix metalloproteinase (MT1-MMP) depends on adhesion, force generation and rigidity sensing of the cell. Melanoma cells (MV3 clone) stably transfected with M...
متن کاملMolecules of cell adhesion and extracellular matrix proteolysis in oral squamous cell carcinoma.
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with a poor 5-year survival rate, due in large part to the presence of metastatic disease at initial diagnosis. In recent years, a number of studies have examined the oral tumor microenvironment to asses the potential dynamic balance between extracellular matrix deposition and proteolytic degradation as well as...
متن کاملThe Neural Extracellular Matrix, Cell Adhesion Molecules and Proteolysis in Glioma Invasion and Tumorigenicity
High-grade gliomas are the most prevalent and lethal form of primary intracranial tumors. Despite significant progress in surgical and adjuvant therapeutic treatments for gliomas, patient prognosis still remains dismal. The ability of gliomas to invade the normal surrounding brain tissue contributes to their capacity to evade therapeutic interventions, ultimately leading to tumor recurrence and...
متن کاملExtracellular Matrix Remodeling in Hypertension
Increases in arterial blood pressure cause cumulative changes in tissue structure and function, resulting ultimately in end-organ damage. One of the pathological hallmarks of hypertensive tissue injury is an increase in tissue fibrosis, which leads to reductions in tissue compliance and function. Fibrosis (or sclerosis) occurs as result of marked changes in the amount and composition of the ext...
متن کاملIntroduction: Cell adhesion and extracellular matrix molecules in synaptic plasticity.
This issue of Neuron Glia Biology contains a special collection of original research papers and reviews on the role of cell adhesion and extracellular matrix (ECM) molecules in synaptic plasticity. These molecules are crucially required for building and maintaining synaptic structure during brain development and there is increasing evidence that they also play important roles in modulating dist...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2011
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.079343